|
Symbol Name ID |
Tubb5
tubulin, beta 5 class I MGI:107812 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Dandy-Walker malformation |
Microcephaly |
Primary microcephaly |
Hypoplasia of the brainstem |
Dilated fourth ventricle |
Subcortical band heterotopia |
Focal polymicrogyria |
Cortical dysplasia |
Dysgenesis of the basal ganglia |
Thin corpus callosum |
Partial agenesis of the corpus callosum |
Hypoplasia of the corpus callosum |
Cerebellar vermis hypoplasia |
Cerebellar vermis atrophy |
Localized neuroblastoma |
Ataxia |
Delayed speech and language development |
Intellectual disability |
Global developmental delay |
Motor delay |
| Disease(s) Associated with TUBB | ||||||||||||||||||||
| complex cortical dysplasia with other brain malformations 6 | ||||||||||||||||||||
| congenital symmetric circumferential skin creases 1 |
| Mouse Phenotypes | nervous system phenotype |
increased neuron apoptosis |
decreased brain size |
decreased corpus callosum size |
abnormal putamen morphology |
small thalamus |
small hippocampus |
thin cerebral cortex |
small olfactory bulb |
abnormal cerebellar layer morphology |
small cerebellum |
abnormal neuron morphology |
|
| Availability | Mouse Genotype | ||||||||||||
| Tubb5tm1.1Dak/Tubb5tm1.1Dak Tg(Nes-cre)1Kln/0 (conditional) |
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| Tubb5tm2.1Dak/Tubb5tm2.1Dak Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||
| Tubb5tm1.1Dak/Tubb5+ Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||
| Tubb5tm2.1Dak/Tubb5+ Tg(Nes-cre)1Kln/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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